Damann N, Bahrenberg G, Stockhausen H, Habermann CJ, Lesch B, Frank-Foltyn R, Lee J, Ann J, Christoph T.
In vitro characterization of the thermoneutral transient receptor potential vanilloid-1 (TRPV1) inhibitor GRTE16523.
Eur J Pharmacol. (2020) doi: 10.1016/j.ejphar.2020.172934.
https://pubmed.ncbi.nlm.nih.gov/31954706/?from_single_result=31954706

 

Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K.
Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system.
Drug Des Devel Ther 13: 1033-1047 (2019)
https://www.dovepress.com/getfile.php?fileID=48858

 

Buschmann H, Handler N
How to conduct forced degradation studies – Scope and regulatory requirements.
Part 1: Pharm. Ind. 2019 (81), 1192-1196; Part 2: Pharm. Ind. 2019 (81), 1401-1409; Part 3: Pharm. Ind. 2020 (82), 55-61.
https://www.ecv.de/suse_search.php?suseMode=word&suseCookie=iv7c5cp6v0h9d05oo3o322c1d7&suseWord=How+to+conduct+forced+degradation+studies+

 

Buschmann H, Holzgrabe U, Jung D.
„Unerwartet“ verunreinigt – Eine kritische Betrachtung anlässlich einer neuen Meldung zu NDMA in Pioglitazon, Dtsch. Apoth. Ztg. 2019 (20), 50-58.
https://www.deutsche-apotheker-zeitung.de/daz-az/2019/daz-20-2019/unerwartet-verunreinigt

 

Christoph T, Kögel B, Schiene K, Peters T, Schröder W.
Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis.
Biochem Biophys Res Commun. (2018) 500:456-461. https://pubmed.ncbi.nlm.nih.gov/29660342/?from_single_result=29660342

 

Petersen KU. Pepsin and its importance for functional dyspepsia: Relic, regulator or remedy? Dig Sci 36: 98-105 (2018)
https://www.ncbi.nlm.nih.gov/pubmed/?term=Pepsin+and+its+importance+for+functional+dyspepsia

 

Christoph T, Raffa R, De Vry J, Schröder W.
Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model.
Pharmacol Res Perspect. (2018) 6(6):e00444. doi: 10.1002/prp2.444. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6262002/

 

Buschmann H, Holzgrabe U Dtsch. Apoth. Ztg.
NDMA in Valsartan – Eine Spurensuche, 2018 (29), 22ff.
https://www.deutsche-apotheker-zeitung.de/daz-az/2018/daz-29-2018/ndma-in-valsartan

 

Handler N, Buschmann H.
Drug Selectivity: An Evolving Concept in Medicinal Chemistry, Wiley-VCH, 520 pages, ISBN-10: 3527335382 (2018).
https://doi.org/10.1002/cmdc.201800493

 

Petersen KU, Kops M, Heintze K.
Analgetika der WHO-Stufe 1 zur Behandlung von (Migräne-) Kopfschmerzen.
WHO step 1 analgesics in the treatment of (migraine) headache.
Pharmakon 5, 69-74 (2017).
www.ingentaconnect.com/contentone/govi/pmakon/2017/00000005/00000001/art00010

 

Emmanuel A, Mattace-Raso F, Neri MC, Petersen KU, Rey E, Rogers J. Constipation in older people: A consensus statement. Int J Clin Pract. 71(1) (2017)
https://www.researchgate.net/publication/311519102_Constipation_in_older_people_A_consensus_statement

 

Quenelle D.C: Birkmann, A.; Goldner, T; Pfaff, T.; Zimmermann, H.; Bonsmann, S; Collins D.J.; Rice, T.L.; Prichard, M.N.(2017): Efficacy of Pritelivir and Acyclovir in the Treatment of Herpes Simplex Virus Infections in a Mouse Model of Herpes Simplex Encephalitis. Antiviral Research, 442.
https://www.sciencedirect.com/science/article/abs/pii/S0166354217306216?via%3Dihub

 

Carta, F. Birkmann, A., Pfaff, T., Buschmann, H., Schwab, W. Zimmermann, H., Maresca, A., Supuran, C. T. (2017): Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action. J. Med. Chem., 60, 3154−3164.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00183

 

Loryan I, Hoppe E, Hansen K, Held F, Kless A, Linz K, Marossek V, Nolte B, Ratcliffe P, Saunders D, Terlinden R, Wegert A, Welbers A, Will O, Hammarlund-Udenaes M.
Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development.
Mol Pharm. 2017 Dec 4;14(12):4362-4373
https://www.ncbi.nlm.nih.gov/pubmed/?term=29099189

 

Klotz U, Koop H, Labenz J, Petersen KU (Petersen KU, Hrsg.).
PPI in der Offizin.
Sicherer Umgang mit nicht rezeptpflichtigen Protonenpumpenhemmern.
Dustri-Verlag Karl Feistle, München-Deisenhofen (2016).
www.amazon.de/PPI-Offizin-Sicherer-rezeptpflichtigen-Protonenpumpenhemmern/dp/387185509X

 

Petersen KU.
Rezeptfrei erhältliche Schmerzmittel.
Intensiv- und Notfallbehandlung 40 (Suppl): S1-S27 (2015).

 

Lohmer LL, Schippers F, Petersen KU, Stoehr T, Schmith VD. Time-to-event modeling for remimazolam for the indication of induction and maintenance of general anesthesia. J Clin Pharmacol 60: 505-514 (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079111/

 

Petersen KU, Malfertheiner P, Mössner J. The Role of sphere size in the context of pancreatin therapy for exocrine pancreatic insufficiency: A systematic review. J Gastrointestin Liver Dis 30: 132-141 (2021)
https://www.jgld.ro/jgld/index.php/jgld/article/view/2985

 

Kops MS, Pesic M, Petersen KU, Schmalix WA, Stöhr T. Impact of concurrent remifentanil on the sedative effects of remimazolam, midazolam and propofol in cynomolgus monkeys. Eur J Pharmacol 890 (2021) 173639 (2021)

 

Hillewaert V, Pusecker K, Sips L, Verhaeghe T, de Vries R, Langhans M, Terlinden R, Timmerman P.
Determination of tapentadol and tapentadol-O-glucuronide in human serum samples by UPLC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15;981-982:40-7.
https://www.ncbi.nlm.nih.gov/pubmed/?term=25600054

 

Rutten K, Schiene K, Robens A, Leipelt A, Pasqualon T, Read SJ, Christoph T.
Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation.
Eur J Pain (2014) 18:204-12.
https://pubmed.ncbi.nlm.nih.gov/23853119/?from_single_result=23853119

 

Kögel B, Terlinden R, Schneider J.
Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs.
Vet Anaesth Analg. 2014 May;41(3):297-304.
https://www.ncbi.nlm.nih.gov/pubmed/?term=24576316

 

Heintze K, Petersen KU.
The case of drug causation of childhood asthma: antibiotics and paracetamol.
Eur J Clin Pharmacol. (2013 Jun); 69(6):1197-209. doi: 10.1007/s00228-012-1463-7. Epub 2013 Jan 5
www.ncbi.nlm.nih.gov/pmc/articles/PMC3651816

 

Morgenstern ECA, Heintze K.
[Effectiveness of analgesic combinations in the self-medication.] Fixe Analgetika-Kombinationen, Viel besser als ihr Ruf?
MMW Fortschritte der Medizin (2013) 155(9):49-51.
link.springer.com/article/10.1007/s15223-014-0429-2

 

Christoph T, Schröder W, Tallarida RT, De Vry J, Tzschentke TM.
Spinal-supraspinal and intrinsic µ-opioid receptor agonist-norepinephrine reuptake inhibitor (MOR-NRI) synergy of tapentadol in diabetic heat hyperalgesia in mice.
J Pharmacol Exp Ther (2013) 347:794-801.
https://pubmed.ncbi.nlm.nih.gov/24051022/?from_single_result=24051022

 

Buschmann H.
Tapentadol-from morphine and tramadol to the discovery of tapentadol.
Edited by: Fischer, J.; Ganellin, C.R.; Rotella, D.P
Analogue-Based Drug Discovery III (2013), 295-318.
onlinelibrary.wiley.com/doi/10.1002/9783527651085.ch12/summary

 

Göhler K, Brett M, Smit JW, Rengelshausen J, Terlinden R.
Comparative pharmacokinetics and bioavailability of tapentadol following oral administration
of immediate- and prolonged-release formulations. Int J Clin Pharmacol Ther. 2013 Apr;51(4):338-48.
https://www.ncbi.nlm.nih.gov/pubmed/?term=23357834

 

Raffa RB, Buschmann H, Christoph T, Eichenbaum G, Englberger W, Flores CM, Hertrampf T, Koegel B, Schiene K, Strassburger W, et al.
Mechanistic and functional differentiation of tapentadol and tramadol.
Expert Opinion on Pharmacotherapy (2012), 13(10), 1437-1449.
www.ncbi.nlm.nih.gov/pubmed/22698264

 

Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Fernández JA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C. Weiler H, Hauer-Jensen M.
Pharmacological targeting of the thrombomodulin–protein C pathway mitigates radiation toxicity.
Nature Med 18: 1123-1129 (2012).
www.ncbi.nlm.nih.gov/pmc/articles/PMC3491776/

 

Galle J, Kleophas W, Dellanna F, Schmid VH, Forkel C, Dikta G, Krajewski V, Fuchs W, Forst T, Pfützner A.
Comparison of the Effects of Pioglitazone versus Placebo when Given in Addition to Standard Insulin Treatment in Patients with Type 2 Diabetes Mellitus Requiring Hemodialysis: Results from the PIOren Study.
Nephron Extra. (2012 Jan); 2(1):104-14.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3383235

 

Buschmann H, Heintze K, Morgenstern E.
Paracetamol – ein moderner Klassiker unter falschem Verdacht [Acetaminophen – A modern classic under suspicion]
MMW-Fortschritte der Medizin (2011), 153, 128-136
publications.rwth-aachen.de/record/232788

 

Kops M, Paulus W, Heintze K, Petersen KU.
Paracetamol: altbewährt oder riskant?
Deutsche Apotheker Zeitung (2011) 151(7): 68-72.
www.deutsche-apotheker-zeitung.de/daz-az/2011/daz-7-2011/paracetamol-altbewaehrt-oder-riskant

 

Pfützner A, Schöndorf T, Tschöpe D, Lobmann R, Merke J, Müller J, Lehmann U, Fuchs W, Forst T.
PIOfix-Study: Effects of Pioglitazone/Metformin fixed combination in comparison to a combination of Metformin with Glimepiride on diabetic dyslipidemia.
Diabetes Technol Ther. (2011 Jun);13(6):637-43.
www.ncbi.nlm.nih.gov/pubmed/21457065

 

Forst T, Weber M, Pfützner A, Kleine I, Löbig M, Hohberg C, Fuchs W.
C-Peptide and Intima Media Thickness in Type 2 Diabetes Mellitus Treated with Pioglitazone.
Diabetes Stoffw Herz (2011) 20: 65 – 68.
www.researchgate.net/publication/287414313_C-Peptide_and_Intima_Media_Thickness_in_Type_2_Diabetes_Mellitus_Treated_with_Pioglitazone

 

Petersen KU.
Pharmakokinetische Interaktionen und ihre Beurteilung. Klinische Betrachtungen zur Relevanz von Interaktionen der Protonenpumpenhemmer Omeprazol und Pantoprazol in der Selbstmedikation.
Med Monatsschr Pharm 34: 270-278 (2011).
www.medmopharm.de/archiv/verzeichnis/2011/08.html

 

Petersen KU.
Paracetamol und die Leber. Schäden bei zugelassenen Dosen?
Münchener Med Wochenschr – Fortschr Med 153: 137–142 (2011).
www.springermedizin.de/paracetamol-und-die-leber/10319378

 

Hanefeld M, Schaper F, Appelt D, Fuchs W.
Effects of pioglitazone versus simvastatin on biomarkers of inflammation in patients on high cardiovascular risk.
Horm Metab Res. (2011 Dec) 43(13):980-3.
www.ncbi.nlm.nih.gov/pubmed/22068809

 

Schröder W, Tzschentke TM, Terlinden R, De Vry J, Jahnel U, Christoph T,
Tallarida RJ.
Synergistic interaction between the two mechanisms of action of tapentadol in analgesia.
J Pharmacol Exp Ther. 2011 Apr;337(1):312-20.
https://www.ncbi.nlm.nih.gov/pubmed/?term=21262850

 

Heintze K.
Hörschäden durch Analgetika: ein neues Problem?
Deutsche Apotheker Zeitung (2010) 150: 66-70.
www.deutsche-apotheker-zeitung.de/daz-az/2010/daz-10-2010/hoerschaeden-durch-analgetika-ein-neues-problem

 

Fischbach W, Darius H, Gross M, Koop H, Kruck I, Petersen KU.
Gleichzeitige Anwendung von Thrombozytenaggregationshemmern und Protonen¬pumpeninhibitoren (PPIs). Positionspapier der Deutschen Gesellschaft für Verdauungs- und Stoff¬wechsel-krankheiten (DGVS) und der Deutschen Gesellschaft für Kardiologie (DGK).
Kardiologe 4: 353-364 (2010) and Z Gastroenterol 48: 1-8 (2010).
leitlinien.dgk.org/files/2010_Positionspapier_Thrombozytenaggregationshemmer_Protonenpumpeninhibitoren_PPI.pdf

 

Xu XS, Smit JW, Lin R, Stuyckens K, Terlinden R, Nandy P.
Population pharmacokinetics of tapentadol immediate release (IR) in healthy subjects and patients with moderate or severe pain.
Clin Pharmacokinet. 2010 Oct;49(10):671-82.
https://www.ncbi.nlm.nih.gov/pubmed/?term=20818833

 

Terlinden R, Kogel BY, Englberger W, Tzschentke TM.
In vitro and in vivo characterization of tapentadol metabolites.
Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):31-8.
https://www.ncbi.nlm.nih.gov/pubmed/?term=20383344

 

Smit JW, Oh C, Rengelshausen J, Terlinden R, Ravenstijn PG, Wang SS, Upmalis D, Mangold B.
Effects of acetaminophen, naproxen, and acetylsalicylic acid on tapentadol pharmacokinetics: results of two randomized, open-label, crossover, drug-drug interaction studies.
Pharmacotherapy. 2010 Jan;30(1):25-34.
https://www.ncbi.nlm.nih.gov/pubmed/?term=20030470

 

Heintze K.
Diskussion um sichere Paracetamol-Dosierung.
Deutsche Apotheker Zeitung (2008) 148: 64-70.
www.deutsche-apotheker-zeitung.de/daz-az/2008/daz-29-2008/diskussion-um-sichere-paracetamol-dosierung

 

Forst T, Wilhelm B, Pfützner A, Fuchs W, Lehmann U, Schaper F, Weber M, Müller J, Konrad T, Hanefeld M.
Investigation of the vascular and pleiotropic effects of atorvastatin and pioglitazone in a population at high cardiovascular risk.
Diabetes Vasc Dis Res (2008) 5:298–303.
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McMillan CJ, Livingston A, Clark CR, Dowling PM, Taylor SM, Duke T, Terlinden R.
Pharmacokinetics of intravenous tramadol in dogs.
Can J Vet Res. 2008 Jul;72(4):325-31.
https://www.ncbi.nlm.nih.gov/pubmed/?term=18783021

 

Kneip C, Terlinden R, Beier H, Chen G.
Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.
Drug Metab Lett. 2008 Jan;2(1):67-75.
https://www.ncbi.nlm.nih.gov/pubmed/?term=19356073

 

Petersen KU, Labens J, Heintze K.
Pharmaka mit Wirkungen auf den Gastrointestinaltrakt.
Pharmakologie und Toxikologie, Ed. Estler CJ.
Schattauer Verlag, Stuttgart; p. 597 – 636; 6. Ed. (2007).

 

Friderichs E, Christoph T, Buschmann H.
Analgesics and Antipyretics
In: Ullmann’s Encyclopedia of Industrial Chemistry
Wiley-VHC, Weinheim, p 1-97 (2007).
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Terlinden R, Ossig J, Fliegert F, Lange C, Göhler K.
Absorption, Metabolism, and Excretion of 14C-Labeled Tapentadol HCl in Healthy Male Subjects.
Eur J Drug Metab Pharmacokinet. 2007 Jul-Sep; 32(3):163-9.
www.ncbi.nlm.nih.gov/pubmed/18062408

 

Terlinden R, Uragg H, Göhler K, Kneip C.
Pharmacokinetics of chlormadinone acetate following single and multiple oral dosing of chlormadinone acetate (2 mg) and ethinylestradiol (0.03 mg) and elimination and clearance of a single dose of radiolabeled chlormadinone acetate.
Contraception. 2006 Sep;74(3):239-44.
https://pubmed.ncbi.nlm.nih.gov/16904418/?from_single_result=16904418

 

Winter W, Deubner R, Holzgrabe U.
Multivariate analysis of nuclear magnetic resonance data – characterization of critical drug substance quality of gentamicin sulphate.
J Pharm Biomed. Anal. (2005) 38: 833-839.
www.ncbi.nlm.nih.gov/pubmed/16087045

 

Hoie, LH, Morgenstern ECA., Gruenwald J., Graubaum H-J, Busch R, Lüder W, Zunft H-JF.
A double-blind, placebo controlled trial compares the cholesterol-lowering effects of two different soy protein preparations in hypercholesterolemic subjects. Soy phospholipids and fiber enhance the cholesterol-lowering effect of soy protein.
European J. of Nutrition (2005) 44 (2): 65-71.
www.researchgate.net/publication/8402722_A_double-blind_placebo-controlled_clinical_trial_compares_the_cholesterollowering_effects_of_two_different_soy_protein_preparations_in_hypercholesterolemic_subjects

 

Schindler C, Schweizer J, Müller A, Koch R, Hellner G, Fuchs W, Kirch W.
Candesartan treatment for peripheral occlusive arterial disease after stent angioplasty. A randomised, placebo-controlled trial.
Clin Drug Invest 25 (2005) 89-97.
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Kirshner, JR, Karpova, AY, Kops M, Howley PM.
Identification of TRAIL as an interferon regulatory factor 3 transcriptional target.
J Virol. (2005) 79: 9320-9324
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Bönner G, Fuchs W.
Fixed combination of candesartan with hydrochlorothiazide in patients with severe primary hypertension.
Curr Med Res Opin 20 (2004) 597-602.
www.ncbi.nlm.nih.gov/pubmed/15140325

 

Hermansen K, Dinesen B, Hoie LH, Morgenstern E, Gruenwald J.
Effects of soy and other natural products on LDL:HDL ratio and other lipid parameters: A literature review.
Advanced Therapeutics (2003) 20 (1): 50-78.
www.ncbi.nlm.nih.gov/pubmed/12772818

 

Malfertheiner P, Mössner J, Fischbach W, Layer P, Leodolter A, Stolte M, Demleitner K, Fuchs W.
Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia.
Aliment Pharmacol Ther. 18 (2003) 615-25.
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Buschmann H, Christoph T, Friderichs E, Maul C, Sundermann B.
Analgesics – In: Chemistry & Pharmacology to Clinical Application.
604 pages, Wiley-VCH, ISBN 3-527-30403-7, (2002).

 

Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM.
Interferon regulatory factor-3 is an in vivo target of DNA-PK.
Proc Natl Acad Sci USA. (2002) 99: 2818-2823.
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Rex A, Morgenstern E, Fink H.
Anxiolytic-like effects of Kava-Kava in the elevated plus maze test-a comparison with diazepam.
Progress of Pharmacology and Toxicology, 26 (2002) 26: 855-860.
www.ncbi.nlm.nih.gov/pubmed/12369257

 

Morgenstern, E, Stattmann A, Grosse-Siestrup C, Stahl K, von Bayer H.
Ergebnisse zur pharmakologischen Untersuchung von Substanzen im Modell der physiologischen ex vivo-Hämoperfusion der isolierten Niere, pp 451-452. In: Forschung ohne Tierversuche 2000,
Schöffl H, Spielmann H, Gruber FP, Appl H, Harrer F, Pfaller W, Tritthart HA. Ersatz und Ergänzungsmethoden zu Tierversuchen, Ed. H. Schöffl, H. Spielmann und H. A. Tritthart. Springer-Verlag Wien, New York (2000).
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Trost M, Kochs G, Haller O.
Characterization of a novel serine/threonine kinase associated with nuclear bodies.
J Biol Chem (2000) 275: 7373-7377.
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Murthy BV, Pandya KS, Booker PD, Murray A, Lintz W, Terlinden R.
Pharmacokinetics of tramadol in children after i.v. or caudal epidural administration.
Br J Anaesth. 2000 Mar;84(3):346-9.
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Lintz W, Becker R, Gerloff J, Terlinden R.
Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 4th communication: drops (without ethanol).
Arzneimittelforschung. 2000 Feb;50(2):99-108.
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Morgenstern, E.
Die antiphlogistische Wirkung von Bronchipret¨ und seiner Komponenten im Rattenpfoten-ödem-Modell. In: Bronchitis – Neue Erkenntnisse zu Wirkungen und Wirksamkeit von Arzneipflanzen.
Ed. R.W. März
Karger Verlag, Freiburg, 1-9 (1998)

 

Wnendt S, Finkam M, Winter W, Ossig J, Raabe G and Zwingenberger K.
Enantioselective Inhibition of TNF-a Release by Thalidomide and Thalidomide-Analogues.
Chirality (1996) 8: 390-396.
www.ncbi.nlm.nih.gov/pubmed/8900028

 

Wöhrmann T, Kögel B-Y, Schneider J, Matthiesen T.
The beagle dog as a predictor of gastrointestinal findings in humans caused by the prostacyclin analogue taprostene.
Exp Toxic Pathol. (1994) 46: 71-73.
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Winter W, Frankus E.
Thalidomide enantiomers.
The Lancet (1992) 339: 365.
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Straßburger W, Winter W, Steffens GJ, Günzler WA and Flohé L.
Computer Aided Protein Design: Three Dimensional Model Building of the Saruplase Structure.
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Springer-Verlag Berlin Heidelberg, (1991) S. 159-166.
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Winter W.
Naxaprostene.
Drugs of the Future (1990) 15: 233-236.